Published 2000
by Chapman & Hall/CRC in Boca Raton .
Written in
Edition Notes
Includes bibliographical references (p. [363]-386) and index.
| Statement | Christopher Jennison and Bruce W. Turnbull.. |
| Contributions | Turnbull, Bruce W. |
| Classifications | |
|---|---|
| LC Classifications | R853.C55 J46 2000 |
| The Physical Object | |
| Pagination | xviii, 390 p. : |
| Number of Pages | 390 |
| ID Numbers | |
| Open Library | OL21116283M |
| ISBN 10 | 0849303168 |
Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses. It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical trials. Download Citation | On Feb 1, , KyungMann Kim and others published Group Sequential Methods with Applications to Clinical Trials | Find, read and cite all the research Author: Kyungmann Kim. Group Sequential Methods with Applications to Clinical Trials (Chapman & Hall/CRC Interdisciplinary Statistics) Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. Medical books Group Sequential Methods with Applications to Clinical Trials. Sequential Methods for Clinical Trials methods” (See Group Sequential Methods in Biomedical Research), a title which unfortunately has led to a false distinction from the wider family of sequential methods of which they are a part. The mathematical answer to the overshoot problem was developed from renewal theory by Siegmund [47]. Earlier theory Cited by: 1.
Synopsis. Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early dissemination of its findings.5/5(1). Group sequential tests for Phase III clinical trials. The setting for this lecture is a Phase III clinical trial, comparing a new treatment against the current standard. Two positive Phase III trials are usually required to support the case made to regulators for the approval of a new Size: KB. Group Sequential Clinical Trial Design with the RCTdesign Package, the width of a 95% con dence interval) or that will allow a decision to reject the null hypothesis to be made with high probability (e.g., 80%, 90%, 95%, or % statistical power) when a speci c alternative hypothesis is true. This includes estimation methods and methods for the determination of an overall p-value. Part I of the book provides the group sequential methods that are necessary for understanding and applying the adaptive design methodology supplied in Parts II and III of the book.
: Group Sequential Methods with Applications to Clinical Trials (Chapman & Hall/CRC Interdisciplinary Statistics) () by Jennison, Christopher; Turnbull, Bruce W. and a great selection of similar New, Used and Collectible Books available now at 4/5(3). This includes estimation methods and methods for the determination of an overall p-value. Part I of the book provides the group sequential methods that are necessary for understanding and applying the adaptive design methodology supplied in Parts II and III of the : $ Group Sequential Methods with Applications to Clinical Trials | Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early . The advantages of sequential methods for clinical trials were also soon noticed. In the medical context the benefits of stopping early can be ethical as well as purely economic. Bross 11 introduced sequential medical plans for comparing two sets of binary responses, and Kilpatrick & Oldham 32 applied the sequential t ‐test to a comparison of Cited by: 1.
